SummaryMultidrug resistanceassociated protein (MRP) and the canalicular multispecific organic anion transporter (cMOAT) are organic anion pumps that have been linked to cytotoxic drug resistance We previously reported the isolation of three human MRP/cMOATrelated transporters, MOATB (MRP4), MOATC (MRP5) and MOATD (MRP3) In the present study we describe the fourth MRP/cMOAT(1998) Belinsky et al Journal of the National Cancer Institute Background Multidrug resistanceassociated protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are transporter proteins that pump organic anions across cellular membranes andOrganic anion transport, mediated by the canalicular multispecific organic anion transporter (cmoat), has been extensively studied The regulation of intracellular vesicular sorting of cmoat by protein kinase C and protein kinase A, and the regulation of cmoatmediated transport in endotoxemic liver disease, have been examined The discovery that the multidrug resistance
Functional Analysis Of A Canalicular Multispecific Organic Anion Transporter Cloned From Rat Liver Journal Of Biological Chemistry
